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KMID : 1140120120170030239
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Cancer Prevention Research
2012 Volume.17 No. 3 p.239 ~ p.243
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Synergistic Anticancer Activity on Mouse Sarcoma by Mixture of Doxorubicin and Water Extract of Albizzia julibrissin
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Yoon Gun-Ae
Chae Seon-Yeong
Kim Kwang-Hyeon
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Abstract
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To confirm synergistic anticancer activity against mouse sarcoma, combination of water extract (HaWD80) of Albizzia julibrissin and doxorubicin was applied in vivo and in vitro. In sarcoma cells treated with HaWD80 or doxorubicin alone, IC50 of HaWD80 and doxorubicin was 12.5μg/ml and 0.25μg/ ml, respectively. In sarcoma cells treated with mixture of HaWD80 and doxorubicin, however, IC50 of HaBD80 and doxorubicin against the cells was 1.6μg/ml and 0.13μg/ml, respectively. Therefore mixture of HaWD80 and doxorubicin appeared synergistic anticancer activity against the sarcoma cells in vitro, because ΣFIC was 0.648μg/ml. Tumor Inhibition Ratio (TIR) of the mouse bearing the sarcoma treated doxorubicin (2.5 mg/kg) or HaWD80 (50 mg/kg) alone was 25.66% and 4.61%, respectively. However,
TIR of the mouse bearing the sarcoma treated simultaneously doxorubicin (2.5 mg/kg) and HaWD80 (50 mg/kg) was 29.28%. Consequently mixture of HaWD80 and doxorubicin appeared synergistic anticancer activity against mouse sarcoma in vitro and in vivo.
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KEYWORD
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Albizzia julibrissin, Mouse sarcoma, Synergistic, Doxorubicin, Julibroside, In vivo
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